Adjuvant Therapy for Resected Non–Small-Cell Lung Cancer with Lymphovascular Invasion
نویسندگان
چکیده
منابع مشابه
Lymphovascular invasion in non-small-cell lung cancer: implications for staging and adjuvant therapy.
BACKGROUND Lymphovascular space invasion (LVI) is an established negative prognostic factor and an indication for postoperative radiation therapy in many malignancies. The purpose of this study was to evaluate LVI in patients with early-stage non-small-cell lung cancer, undergoing surgical resection. METHODS All patients who underwent initial surgery for pT1-3N0-2 non-small-cell lung cancer a...
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Adjuvant chemotherapy is recommended for postoperative stage II-IIIB nonsmall cell lung cancer patients. However, its effect remains controversial in stage IB patients. We, therefore, performed a meta-analysis to compare the efficacy of adjuvant chemotherapy versus surgery alone in stage IB patients. Six electronic databases were searched for relevant articles. The primary and secondary outcome...
متن کاملAdjuvant chemotherapy for completely resected non-small-cell lung cancer.
PURPOSE To conduct a systematic review and to evaluate the impact of postoperative adjuvant chemotherapy on the survival of patients with completely resected non-small cell lung cancer. METHODS Relevant randomized trials and meta-analyses, published as articles or abstracts, were identified through electronic and hand searches by two reviewers. RESULTS Seven meta-analyses and 26 randomized ...
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Surgery remains the mainstay of therapy for early stage non-small cell lung cancer (NSCLC), but even for stage IA, disease relapse rates remain as high as 30%. Patients with completely resected (R0) N1 disease have about a 50% chance of relapse. In the past 5 years, the benefit of adjuvant chemotherapy has finally been demonstrated for patients with lung cancer. Improvements of 5% to 10% 5-year...
متن کاملAdjuvant Chemotherapy for Resected Non–Small-Cell Lung Cancer
Because of the high rate of distant disease recurrence, the 5-year survival of patients who have undergone complete surgical resection of localized non–small-cell lung cancer (NSCLC) is approximately 50%. Initial results from early studies of adjuvant postoperative chemotherapy reported an adverse effect of alkylating agent and older chemotherapy regimens on survival. Cisplatin-based combinatio...
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ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2013
ISSN: 1556-0864
DOI: 10.1097/jto.0b013e3182797f3b